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Ingredient source facts

4,4'-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt (see note 17): EU cosmetic annex conditions and formula evidence

4,4'-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt (see note 17) has identifier matches to Annex III in the acquired 18 May 2026 EU Cosmetics Regulation text. The table distinguishes the substance identity, product-use conditions and recorded limits. Confirm the exact substance/group scope, formula concentration and intended use before applying an entry. This does not certify formula safety or settle Great Britain requirements. The informative CosIng metadata and legal-table references differ; this page does not treat them as interchangeable.

Evidence retrieved 2026-10-06. Source versions and topic-specific limits are listed below.

Exact legal-entry matches and product-use conditions

Exact checksum-valid CAS and/or exact EC identifier in preserved legal identity cells. Group and substance scope are still conditional.

Each line below retains its own concentration basis, conditions and warnings. Blank source cells mean no condition was recorded in that cell; they do not establish unrestricted use.

Annex III · Entry 226

Recorded identity: 4,4′-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt ( 17 )

Matching CAS: 74918-21-1, 81892-72-0 · Matching EC: 278-022-7, 279-845-4

Product use / body siteMaximum concentration and basisOther conditionsWarningsSource
(a) Hair dye substance in oxidative hair dye productsBlank in source(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,2 % calculated as free base (1,8 % as tetrahydrochloride salt).(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.’[2]
(b) Hair dye substance in non-oxidative hair dye products(b) 1,2 % as free base (1,8 % as tetrahydrochloride salt)(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,2 % calculated as free base (1,8 % as tetrahydrochloride salt).(b) Can cause allergic reaction[2] [4]

Linked notes for this entry

  • ( 17 ) The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. [3]

The consolidated text is a dated reference. Current amendments, corrigenda and applicability dates must be checked. EU evidence does not resolve Great Britain rules.

Known facts and deciding inputs

Known context: EU. Ingredient identity is recorded; concentration, intended use, exposure and current legal conditions still need checking.

Source factRecorded valueWhat to check
INCI / recorded name4,4'-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt (see note 17) [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
Common ingredients glossary name1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
CAS identifiers81892-72-0 - 74918-21-1 [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
EC identifiers279-845-4 - 278-022-7 [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
Informative CosIng functionsHAIR DYEING [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
CosIng annex referenceIII [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
CosIng reference entry202 [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
wordingOfConditions(a) The mixing ratio: <img src="images/warning.gif" align="bottom"> Hair colorants can cause severe allergic reactions. (b) Can cause allergic reaction [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
productTypeBodyParts(a) Hair dye substance in oxidative hair dye products [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
other(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt). [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
SCCS opinion referenceRequest for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products, Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004, Opinion on Personal Use of Hair Dyes and Cancer Risk, Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk, Assessment Strategies for Hair Dyes, Opinion on 1,3-Bis(2,4-diaminophenoxy)propane, Memorandum on Hair Dye Substances and their Skin Sensitising Properties, Opinion on 1,3-bis-(2,4-Diaminophenoxy)propane [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
Related regulation reference(EC) 2013/344 [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.
Recorded publication date2013-04-25T00:00:00.000+0200 [1]Check identity, concentration, exposure and use against the current legal annex and any amendments.

Resolve the entry against your actual formula

Use this checklist to gather your business or product details before speaking with a specialist. The items below explain what to record and suggest useful supporting documents. You can add your own answers in the editable project brief.

  1. Does the supplied material fall within these exact entries?

    Put your supplier CAS/EC, substance composition, salt/group membership, purity, physical form and intended function beside each matched entry. A matching identifier does not resolve every group or impurity condition.

    Useful evidence: Supplier specification, composition and certificates of analysis; the exact annex rows above.

  2. Which row governs the finished-product use?

    Compare the finished-product concentration, body site, rinse-off/leave-on use, consumer/professional setting and any exposure restrictions with each row. Preserve the units and calculation basis; do not transfer a limit from a different product-use row.

    Useful evidence: Quantitative formula and use instructions; a row-by-row condition and warning worksheet.

  3. Is a prohibition or trace question involved?

    For Annex II matches, review Article 14 before formulation decisions. Article 17 concerns a separate, conditional non-intended trace situation; it does not grant blanket permission to intentionally add a prohibited substance. Record origin and technical-avoidability evidence for specialist review.

    Useful evidence: Ingredient/impurity origin, manufacturing controls, trace quantities and the cited Article 17 text.

  4. What must reach the safety assessor and Responsible Person?

    Send the reconciled identity, condition table, exposure facts, supplier evidence and unresolved amendment/date questions. Agree formula, assessment and PIF responsibilities before notification or manufacturing handoff.

    Useful evidence: A dated formula-evidence matrix, supplier data, exposure description and document ownership list.

Work packages and dependencies

What needs to happen first

Questions for providers

Sources and data dates

Read the official document in context. The audit details identify the precise locators and preserved versions used for this page.

EUR-Lex — Regulation (EU) 2009/1223 ↗

Consolidated text dated 2026-05-18 · retrieved 2026-10-06

Audit details: precise locators and snapshot identifiers

Source key D05 · snapshot fc7ca1c1b06e5052fbfd81afd57c8ba69d4c215a4fc4a2a8385b9bff94a7b591

  • [2] HTML table[2] in substantive document container (extraction legal-html-tables-2) / own tr[423] · record c0b338c304d8d1e4ad3736ab8003a684a176cabbc6488634a763929312d886e5
  • [3] #E0036 / containing div (linked annex note) · record caf8fe586ccfe0548ad7737b9f5acce33d62f0568878fa3a6078de6f98b26799
  • [4] HTML table[2] in substantive document container (extraction legal-html-tables-2) / own tr[424] · record 4ff9cd3c9161f3fb19134f7a4743544ddcb1d4e6098fc69e8183400d65fe0edc
  • [5] #art_14 · record 9ffeb5c563a32fe8d532de5d352c05f8a9062e1c5d21fd326d5e6c2ea42a84f4
  • [6] #art_17 · record 8ad3194ae1fc45e70495aa637f90457139a0023680e2b880fc4c8a8b4d202c43
  • [7] #art_10 · record 49eb173406b736d6f0b855572abc53b0f52d9543a4d170affa8ae68d6e809718
  • [8] #art_11 · record ba70c2a84c1d6c70eb57a0fd892fcdf584f6142281b03c29be4bd20e6e83844d

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