Ingredient source facts

2-Amino-6-chloro-4-nitrophenol: EU cosmetic annex conditions and formula evidence

2-Amino-6-chloro-4-nitrophenol has identifier matches to Annex III in the acquired 18 May 2026 EU Cosmetics Regulation text. The table distinguishes the substance identity, product-use conditions and recorded limits. Confirm the exact substance/group scope, formula concentration and intended use before applying an entry. This does not certify formula safety or settle Great Britain requirements.

Evidence retrieved 2026-10-06. Source versions and topic-specific limits are listed below.

Exact legal-entry matches and product-use conditions

Exact checksum-valid CAS and/or exact EC identifier in preserved legal identity cells. Group and substance scope are still conditional.

Each line below retains its own concentration basis, conditions and warnings. Blank source cells mean no condition was recorded in that cell; they do not establish unrestricted use.

Annex III · Entry 252

Recorded identity: 2-Amino-6-chloro-4-nitrophenol

Matching CAS: 6358-09-4 · Matching EC: 228-762-1

Product use / body site	Maximum concentration and basis	Other conditions	Warnings	Source
(a) Hair dye substance in oxidative hair dye products	Blank in source	(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %	(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.’	[2]
(b) Hair dye substance in non-oxidative hair dye products	(b) 2,0 %	(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %	(b) ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.’	[2] [3]

The consolidated text is a dated reference. Current amendments, corrigenda and applicability dates must be checked. EU evidence does not resolve Great Britain rules.

Known facts and deciding inputs

Known context: EU. Ingredient identity is recorded; concentration, intended use, exposure and current legal conditions still need checking.

Source fact	Recorded value	What to check
INCI / recorded name	2-Amino-6-chloro-4-nitrophenol [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
Common ingredients glossary name	2-AMINO-6-CHLORO-4-NITROPHENOL [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
CAS identifiers	6358-09-4 [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
EC identifiers	228-762-1 [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
Chemical name	2-Amino-6-chloro-4-nitrophenol [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
CosIng annex reference	III [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
CosIng reference entry	252 [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
maximumConcentration	(b) 2.0% [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
wordingOfConditions	(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. (b) ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.’ [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
productTypeBodyParts	(a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
other	(a) After mixing under oxidative conditions the maximum concentraion applied to hair must not exceed 2.0% [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
SCCS opinion reference	Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products, Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004, Opinion on Personal Use of Hair Dyes and Cancer Risk, Opinion on 2-Amino-6-chloro-4-nitrophenol, Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk, Assessment Strategies for Hair Dyes, Memorandum on Hair Dye Substances and their Skin Sensitising Properties [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
Related regulation reference	(EC) 2013/344 [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.
Recorded publication date	2013-04-25T00:00:00.000+0200 [1]	Check identity, concentration, exposure and use against the current legal annex and any amendments.

Resolve the entry against your actual formula

Use this checklist to gather your business or product details before speaking with a specialist. The items below explain what to record and suggest useful supporting documents. You can add your own answers in the editable project brief.

Does the supplied material fall within these exact entries?
Put your supplier CAS/EC, substance composition, salt/group membership, purity, physical form and intended function beside each matched entry. A matching identifier does not resolve every group or impurity condition.
Useful evidence: Supplier specification, composition and certificates of analysis; the exact annex rows above.
Which row governs the finished-product use?
Compare the finished-product concentration, body site, rinse-off/leave-on use, consumer/professional setting and any exposure restrictions with each row. Preserve the units and calculation basis; do not transfer a limit from a different product-use row.
Useful evidence: Quantitative formula and use instructions; a row-by-row condition and warning worksheet.
Is a prohibition or trace question involved?
For Annex II matches, review Article 14 before formulation decisions. Article 17 concerns a separate, conditional non-intended trace situation; it does not grant blanket permission to intentionally add a prohibited substance. Record origin and technical-avoidability evidence for specialist review.
Useful evidence: Ingredient/impurity origin, manufacturing controls, trace quantities and the cited Article 17 text.
What must reach the safety assessor and Responsible Person?
Send the reconciled identity, condition table, exposure facts, supplier evidence and unresolved amendment/date questions. Agree formula, assessment and PIF responsibilities before notification or manufacturing handoff.
Useful evidence: A dated formula-evidence matrix, supplier data, exposure description and document ownership list.

Work packages and dependencies

Conditional: Formula-condition reconciliation and EU safety/PIF handoff — Resolve the matched annex entries against supplier identity, function, concentration basis, product use, warnings and linked notes. Agree assessment, PIF and Responsible Person responsibilities after the findings.
Optional: Manufacturing and supplier-evidence handoff — If manufacturing support is needed, prepare material specifications, quantitative formula, batch controls and the condition/warning evidence matrix for the assessor and Responsible Person.

What needs to happen first

EU+UK Cosmetics Compliance → Cosmetic Contract Manufacturers & Private Label: Resolve the formula-condition and warning questions before agreeing manufacturing release evidence; coordinate the assessor, Responsible Person and manufacturer handoff.

Questions for providers

Which exact annex entry and product-use subrow matches our material and finished-product use, and which alternatives should be excluded?
What evidence resolves group/salt, impurity, concentration-basis and warning conditions in the matched rows?
Which amendments or applicability dates change this dated reference, and how will EU and GB evidence be checked separately?

Sources and data dates

Read the official document in context. The audit details identify the precise locators and preserved versions used for this page.

European Commission — CosIng ingredient information ↗

Scoped live response 2026-10-06T15:16:55.463Z · retrieved 2026-10-06

[1] Official dataset record — exact position in audit details

Audit details: precise locators and snapshot identifiers

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EUR-Lex — Regulation (EU) 2009/1223 ↗

Consolidated text dated 2026-05-18 · retrieved 2026-10-06

Audit details: precise locators and snapshot identifiers

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